• In vitro studies with soman inhibited

  2024-06-17

  

  In vitro studies with soman-inhibited, non-aged AChE revealed a species dependent reactivating potency of HI-6 and MMB-4. With guinea pig AChE second order reactivation rate constants of 0.051 and 0.038mM−1min−1 were determined for HI-6 and MMB-4, respectively (Luo et al., 2007). Corresponding value

• Moreover our present work suggests that AXL

  2024-06-17

  

  Moreover, our present work suggests that AXL could be a modulator of sunitinib response, at least for cell lines that present high endogenous levels of this RTK activation, since we observed an increased responsiveness to sunitinib in WAY-100635 mg activated with AXL receptor ligand. A role for AXL

• br Disclaimer Statement br Acknowledgments br Introduction M

  2024-06-17

  

  Disclaimer Statement Acknowledgments Introduction Metabolic changes are a common feature of cancerous tissues. Mutations in oncogenes and tumor suppressor genes cause alterations to multiple intracellular signaling pathways that rewire tumor cell metabolism and re-engineer it to allow enhan

• ASK belongs to the family of MAPKKK ASK mediated

  2024-06-17

  

  ASK1 belongs to the family of MAPKKK. ASK1-mediated apoptosis is involved in the pathogenesis of several diseases such as I/R injury, infectious diseases and neurodegenerative disorders [33], [34], [35]. ASK1 can be activated through different mechanisms. One mechanism is that oxidative stress dire

• br Materials and methods br Results br Discussion Because

  2024-06-17

  

  Materials and methods Results Discussion Because the Ser/Thr kinase domain of LRRK2 is homologous to that of other MLK family proteins belonging to the MAP3K superfamily, LRRK2 is suggested to be involved in MAPK signaling and activation of neuronal cell death by phosphorylating its downstr

• br Results br Discussion br STAR Methods br Author

  2024-06-17

  

  Results Discussion STAR★Methods Author Contributions Acknowledgments We thank Angela Walker for assistance with the manuscript; Junlin Liu, Xiangxiang Gu, Na Chen, Lu Xue, and the BV Core Facility of iHuman Institute for their support; scientists and colleagues at Amgen Inc., Zhulun W

• To investigate if WP increased CAT activity in cells

  2024-06-17

  

  To investigate if WP increased CAT activity in cells, C2C12 muscle Dyngo-4a were treated with 0.1 to 0.4 mg/mL of WP (80.05% protein) for 24 h and then stressed with 0.75 mM H2O2 for 1 h (Xu et al., 2011). The CAT activity was significantly enhanced from 15.1 ± 0.7 to 23.7 ± 1.3 U/mg of total cellul

• br Obstructing SNARE zippering Sharma

  2024-06-17

  

  Obstructing SNARE “zippering” Sharma et al. demonstrated for the first time that in the postmortem AD brains, the level of SNARE complex formation, which is necessary for driving synaptic vesicle fusion at the presynaptic active zone, is significantly reduced [123]. In the absence of changes in e

• We designed SSOs that block APP exon splicing and

  2024-06-17

  

  We designed SSOs that block APP exon 17 splicing and induce the production of an alternatively spliced APP mRNA lacking exon 17 (APPΔex17). APPΔex17 mRNA encodes an APP protein isoform that lacks 49 resazurin synthesis including the γ-secretase cleavage sites that give rise to the toxic, AD-associa

• MAPs require divalent transition metal ions as cofactors for

  2024-06-14

  

  MAPs require divalent transition metal ions as cofactors for activity [21]. Previous studies on MAPs from different organisms indicate cobalt ions to be the most preferred divalent metal activator [22]. However, MAPs also exhibit activity with other divalent cations like Mn(II), Ca(II), Ni(II) or Fe

• br Materials and methods br Results br Discussion Intracellu

  2024-06-14

  

  Materials and methods Results Discussion Intracellular metabolic pathways of sugar, such as glycolysis and TCA cycle, provide material and energy for the synthesis of other substances, including amino acids. Thus, the content of sugars and their metabolic pathways are important for amino Ch

• Various compounds have been designed to

  2024-06-14

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic TCS PIM-1 1 sale moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to b

• In our previous study we found

  2024-06-14

  

  In our previous study we found that the total activity of aldehyde dehydrogenase in cancer histamine inhibitors of RCC is at the same level as in normal renal tissue [10]. These findings are similar to our results in serum patients with renal cancer. There is no significant difference between ALDH

• br Downstream signalling of AKT A consensus phosphorylation

  2024-06-14

  

  Downstream signalling of AKT A consensus phosphorylation motif has been described for AKT substrates: R-X-R-X-X-S/T-B where X represents any amino CRT0044876 and B represents bulky hydrophobic residues (Alessi, Caudwell, Andjelkovic, Hemmings, & Cohen, 1996). Numerous AKT substrates have been pu

• guanabenz Notably both circulating adiponectin and adipsin w

  2024-06-14

  

  Notably, both circulating adiponectin and adipsin were equally diminished by about 50% in Arfrp1 mice consistent with several studies reporting overlapping trafficking routes for their secretion from 3T3-L1 guanabenz which was strikingly inhibited upon ablation of TfR-positive endosomes [18,26,33].

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