• The indigenous populations living at high mountain regions o

  2021-04-12

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human Celecoxib to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopulmonary and haematolog

• Host cell invasion by tachyzoites relies on the secretion of

  2021-04-12

  

  Host cell invasion by tachyzoites relies on the secretion of numerous secretory proteins and plays a crucial role in maintaining infection [6]. ESA released by tachyzoites are highly immunogenic and induce either antibody-dependent or cell-mediated protective immunity [11], [44], [45]. To investigat

• In mammals NETs contain DNA and antimicrobial proteins compo

  2021-04-12

  

  In mammals, NETs contain DNA and antimicrobial proteins composed mainly of nuclear histones, granule-derived neutrophil elastase, myeloperoxidase, lactoferrin, pentraxin, and gelatinase among others [11], [46], [47], [48]. In fish, NETs-like structures have been observed, and DNA staining and immuno

• br DDR mediated signaling DDRs initiate signaling pathways

  2021-04-12

  

  DDR-mediated signaling DDRs initiate signaling pathways in a context and cell type-dependent manner. For instance, DDR1 was reported to activate ERK in vascular smooth muscle Zebularine (Lu et al., 2011), to inhibit ERK in mesangial cells (Curat and Vogel, 2002), and to have no effect on ERK acti

• Regardless of its effect on EBV

  2021-04-12

  

  Regardless of its effect on EBV infection, the chemokine system has been found to be regulated in both nasopharyngeal cancer and Hodgkin lymphoma. As such, Hodgkin and Reed–Sternberg (HRS) cells from Hodgkin lymphoma and nasopharyngeal carcinoma cells have been shown to express CXCL8 and CCL17. Furt

• In pregnancy maternal uterine spiral artery SA

  2021-04-12

  

  In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK igf1r inhibitor (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans an

• Itch also known as astrophin interacting protein AIP is a

  2021-04-12

  

  Itch, also known as astrophin-1 interacting protein-4 (AIP4), is a HECT domain-E3 ligase. It was discovered in 1998 in mouse coat color genetic studies which displayed the disruption caused by the Itch gene inducing a lethal autoimmune inflammatory condition. The substrates of Itch are transmembrane

• To get an indication whether GBM derived OHC could

  2021-04-12

  

  To get an indication whether GBM-derived 25-OHC could act as a chemotactic signal for monocytes, lipid extracts of GM133 media were used in THP-1 migration assays. Although an indirect approach, these experiments revealed that medium lipid extracts induced monocyte migration in a quantitatively comp

• br APC C Uses a Dynamic Cullin RING

  2021-04-12

  

  APC/C Uses a Dynamic Cullin–RING Mechanism to Elongate Polyubiquitin Chains Human APC/C generates Lys11-linked poly-Ub chains through an entirely different mechanism, via the distinctive E2 enzyme, UBE2S 30, 31, 32. Although APC2 and APC11 are necessary and sufficient to activate UBE2S, the mecha

• br E mediated E discharge

  2021-04-12

  

  E3-mediated E2 discharge E3 ligases simultaneously interact with the substrate and the SUMOD charged E2 enzyme to catalyze the discharge of the thioester-bound SUMOD from the E2 to the substrate. E3 interaction with SUMOD via a SIM results in a closed conformation which is highly reactive and lea

• br Methods br Results br Discussion To our knowledge this

  2021-04-12

  

  Methods Results Discussion To our knowledge, this is the first report to investigate the association between DBH genotype and pDβH activity in Han Chinese subjects. We also examined the relationship among DBH gene polymorphisms, pDβH activity and cognitive function in patients with schizoph

• br Regulation of DGK activity Activation of the DGKs

  2021-04-12

  

  Regulation of DGK activity Activation of the DGKs is complex and unique for each DGK isotype. In most cases, DGKs must translocate to a membrane compartment to access DAG. However, translocation does not necessarily activate the enzyme [57]. In addition, DGK activity can be modified by other cofa

• br Materials and Methods br

  2021-04-12

  

  Materials and Methods Results Discussion HSCs have been identified as major collagen-producing Irinotecan receptor in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble

• The modes of action of insecticides

  2021-04-12

  

  The modes of action of insecticides are classified by the Insecticide Resistance Action Committee (IRAC) [6]. In this classification, a large proportion of insecticides are categorized as nerve- and muscle-targeting insecticides, which encompass GABACl antagonists (Group 2) and GluCl allosteric modu

• Benzoylmesaconitine Although many of the genetic

  2021-04-10

  

  Although many of the genetic changes remain to be elucidated, there is evidence to support a difference in incidence and rate of rupture of cerebral aneurysms between men and women, and between pre- and postmenopausal women, suggesting that aneurysm formation may be affected by hormonal changes.18,

13901 records 621/927 page Previous Next First page 上5页 621622623624625 下5页 Last page