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The Kaempferia parviflora extract met the criteria for a
2019-10-21
The Kaempferia parviflora extract met the criteria for a non-competitive interaction with CYP1A1 based on the decrease of Vmax and unchanged Km. The high Ki value and low IC50, as well as the high Km value was indicative of the weakness of the interaction between the Kaempferia parviflora extract an
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In pregnancy maternal uterine spiral artery SA remodeling
2019-10-21
In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK Orlistat receptor (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans a
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br RING dimerization RING type domains are found in many
2019-10-21
RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain Schaftoside synthesis (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF
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Herein we report the expression of shrimp
2019-10-19
Herein we report the expression of shrimp Cdk-2 in hepatopancreas, gills and muscle, finding higher expression in hepatopancreas and gills and lower expression in muscle. No significant changes due to hypoxia and hypoxia reoxygenation were detected on the expression of Cdk-2 in hepatopancreas and gi
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Abha et al reported Natural coumarinolignoids isolated from
2019-10-19
Abha et al. reported Natural coumarinolignoids isolated from the seeds of Cleome viscosa consist of a racemic mixture of cleomiscosins A 19, B 20 and C 21 and were screened for anti-inflammatory activity through mol. docking and QSAR studies by using reported in vivo activity of Swiss albino mice. B
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It is of interest to point out that
2019-10-19
It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general si cid clinical of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 defici
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Early studies from the mollusk Aplysia reported the
2019-10-19
Early studies from the mollusk, Aplysia, reported the presence of a unique class of DLPC receptors in neurons, the acetylcholine-gated chloride channels (ACCs) (Kehoe and McIntosh, 1998). Later, studies identified these receptors in the model nematode Caenorhabditis elegans (Putrenko et al., 2005;
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Although MMP might be a downstream target of Src
2019-10-19
Although MMP-9 might be a downstream target of Src kinase signaling (Liu and Sharp, 2011), a direct connection has not been established. We showed for the first time that, in the collagenase-induced ICH model, Src kinase signaling regulates MMP-9 activity and mediates EP1R toxicity. Consistent with
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The rate of protein degradation is often affected by N
2019-10-19
The rate of protein degradation is often affected by N-starvation [12], therefore, we examined the influence of N-starvation against the appearance of CEPs. N-starved cucumber cotyledons contained less amounts of protein and Rubisco, but the temporal changes in protein and Rubisco contents were simi
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Verapamil a calcium channel blocker used
2019-10-18
Verapamil, a calcium channel blocker used clinically as a coronary vasodilator, was amongst the first compounds identified that could reverse MDR and potentiate the effects of MDR1 substrates such as vincristine [15], [16]. Verapamil, along with a number of other MDR1 blockers, have proved largely u
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Our ex vivo analysis demonstrates that IL promotes
2019-10-18
Our ex vivo analysis demonstrates that IL-15 promotes CD122 expression in DGKζ-deficient CD8+ T cells. CD122, which forms a dimer with CD132 in response to IL-2 or IL-15, activates the JAK/STAT and PI3K/mTOR pathways. Whereas antigen-stimulated apomorphine pathway promote IL-2 sensitivity through up
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br Materials and methods br Results br Discussion The
2019-10-18
Materials and methods Results Discussion The first DGAT1 gene was described in the mouse in 1998 [28], and a few years later DGAT2 was identified from the oleaginous fungus Mortierella ramanniana[29]. Although both of them are known as the primary enzymes for de novo TAG biosynthesis, they
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The CYP A genes are
2019-10-18
The CYP3A genes are regulated physiologically by glucocorticosteroids, growth hormone, thyroid hormones and cytokines [13, 20, 30]. It has been shown that glucocorticoid receptor (GR), pregnane X receptor (PXR), constitutive androstane receptor (CAR) and vitamin D receptor (VDR) play an important ro
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The pharmacokinetics properties of compound were evaluated
2019-10-18
The pharmacokinetics properties of compound were evaluated in male Sprague Dawley rats following IV (0.7mg/kg) and oral (2.0mg/kg) dosing. The total body clearance and the terminal half-life were 0.73 L/h/kg and 5.1h, respectively. After oral administration the compound showed good bioavailability
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The present findings suggested that nsEP inhibited
2019-10-18
The present findings suggested that nsEP inhibited CPG2 via deprivation of zinc ions, with no effect on apoenzyme integrity. Zinc may be removed from CPG2 by the electric forces. Within CPG2, each zinc ion was coordinated by one histidine, one glutamate and one aspartate [6]. The nsEP field can alte
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