• Next we evaluated neutralization of

  2019-09-10

  Next, we evaluated neutralization of Jc1, Jc1-N534A, Jc1-ΔHVR1 and Jc1-ΔHVR1-N534A by sera from individuals chronically infected with HCV GT1 and GT2 (Fig. 4A-C).

• In Murray–Darling rainbowfish confirming

  2019-09-09

  In Murray–Darling rainbowfish, confirming the expected in vivo effects of androgenic progestins could be achieved using short-term exposures and determining expression profiles for androgen-responsive genes, or in longer term exposures by monitoring fecundity or the development of male secondary sex characteristics in females.

• Gliptins have become a part of various therapeutic

  2019-09-07

  Gliptins have become a part of various therapeutic regimens to treat type 2 diabetics in recent decades. Gliptins were developed to lower the blood glucose in type 2 diabetes patients and have been shown to be effective [4,5].

• Protein ubiquitination occurs at the lysine residues

  2019-09-06

  Protein ubiquitination occurs at the lysine residues, and is mediated by the sequential reactions of ubiquitin-activating enzyme (E1), conjugating enzyme (E2), and ligase (E3).

• A comparative analysis of the cleavage activity

  2019-09-05

  A comparative analysis of the cleavage activity of different forms of the BoNT/A endopeptidase in reduced conditions with SNAPtide and full-length SNAP-25 substrate is summarized in Fig. 5, Fig. 6.

• Large yellow croaker (Larimichthys crocea) are widely

  2019-09-04

  Large yellow croaker (Larimichthys crocea) are widely cultured in China but have inferior meat texture compared with wild fish. This result results from excess lipid deposition in the muscle, which reduces mechanical strength (Thakur et al., 2003).

• Repulsive interactions towards undesirable substrates

  2019-09-03

  Repulsive interactions towards undesirable substrates are arguably a very efficient means to implement specificity [8]. In particular, it could be assumed that discrimination against a substrate that is larger than the cognate substrate may be achieved easily by restricting the active site and exploiting steric repulsion [12].

• Social interaction is known to be the main source

  2019-09-02

  Social interaction is known to be the main source of stress in human beings (Dickerson and Kemeny, 2004, Tamashiro et al., 2005).

• Conclusions Mulan is a mitochondrial E3

  2019-08-30

  Conclusions Mulan is a mitochondrial E3 ubiquitin ligase with diverse roles in cell growth, cell death, and mitophagy.

• The thermal behavior of the UV-sensitive nanocomposites

  2019-08-29

  The thermal behavior of the UV-sensitive nanocomposites was investigated by DSC before and after irradiation in an extended temperature range (from −40 to 250 °C).

• In this context we initiated a program to

  2019-08-28

  In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in GSK1904529A replication: the host (human) dihydrofolate reductase (DHFR) [21].

• We then analyzed Ki-67 proliferation index as

  2019-08-27

  We then analyzed Ki-67 proliferation index as a categorical variable by using 15%, essentially the median Ki-67 value in the entire study group (see above), to delineate low and high proliferation subgroups.

• A widely accepted mechanism to differentiate

  2019-08-26

  A widely accepted mechanism to differentiate hESCs into cardiomyocytes is through perturbation of the canonical Wnt/β-catenin pathway. Initial Wnt activation is required to form the DSLET [3].

• Tumor DSLET exposed to the effect

  2019-08-24

  Tumor DSLET exposed to the effect of these compounds were shown to become chemo and radio-sensitive. Based on that, it was possible to anticipate the selectivity requirement for DNA-PK inhibition and the best route for their development.

• Acknowledgments Denise Fernandes acknowledges

  2019-08-23

  Acknowledgments Denise Fernandes acknowledges a postdoc fellowship (SFRH/BPD/34289/2006) from the Portuguese Fundação para a Ciência e Tecnologia (FCT) of the Ministry of Science and Technology of Portugal.

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