• br Funding This work was

  2025-02-19

  

  Funding This work was supported by the National Natural Science Foundation of China (grant No. 81573664). Thanks to Jing-xian Yang from the Pharmacology Laboratory of Liaoning University of Traditional Chinese Medicine for support with technology and experimental equipment. Disclosure Confl

• br Author Contributions br Acknowledgments br Introduction C

  2025-02-19

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to hippo signaling tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therape

• MD was the recipient of the Intergroupe

  2025-02-19

  

  MD was the recipient of the Intergroupe Francophone de Cancérologie Thoracique (IFCT) Alain Depierre Grant in 2014. JP was the recipient of the ARISTOT (Association de Recherche, d’Information Scientifique et Thérapeutique en Oncologie Thoracique) grant in 2016. Conflicts of interest statement

• Although several ARIs have reached various

  2025-02-19

  

  Although several ARIs have reached various phases of clinical experimentation however most of them have been withdrawn either due to an insufficient bioavailability, their poor efficacy or adverse side effects. Currently Epalrestat is in clinical use for the treatment of diabetic neuropathy. The sid

• The rank order of agonist potency in turkey

  2025-02-19

  

  The rank order of agonist potency in turkey cardiac chambers demonstrated the predominant presence of the β-adrenergic receptor subtype, in line with the receptor classification by . However, a previous radioligand binding study in the left ventricles of 7-week old turkeys reported the existence of

• Interestingly our transgenic mouse model with macrophages ex

  2025-02-19

  

  Interestingly, our transgenic mouse model with macrophages expressing AdipoR1 showed not only improved insulin sensitivity and inflammation in skeletal muscle and adipose tissues, but fat mass, macrophage and plasma lipid accumulation and foam cell formation was also favorably reduced resulting from

• Involvement of Adiponectin in the regulation of imatinib res

  2025-02-19

  

  Involvement of Adiponectin in the regulation of imatinib resistance in human CML cells has not been hitherto examined. Therefore, in this study, we first established imatinib-resistant K562 CML cells, and then evaluated the effect of Adiponectin in reversing imatinib resistance. The data presented h

• A previous study reported that the serotonergic mechanism wa

  2025-02-19

  

  A previous study reported that the serotonergic mechanism was involved in the psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field (Matsumoto et al., 2004). Sumitaka Inoue et al. (Inoue et al., 2014) reported that pretreatment with a 5-HT1A receptor partial

• br Adenosine receptors and the adaptive immunity T lymphocyt

  2025-02-19

  

  Adenosine receptors and the adaptive immunity T lymphocytes are responsible for the cell-mediated immune response [95]. These cells can be stimulated by the presentation of antigenic moieties by APCs, such as dendritic cells or macrophages [96]. The presentation of antigenic molecules on the APC

• Eeyarestatin I br Introduction Adenosine deaminase ADA which

  2025-02-19

  

  Introduction Adenosine deaminase (ADA), which can catalyze the conversion of AD to inosine by removing an amino group, is a key hydrolytic enzyme of purine metabolism (Conway and Cooke, 1939), and plays an important role in an amount of diseases. For example, an increase of ADA activity in serum

• br Methods and results ACE is

  2025-02-18

  

  Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric Anti-fibrotic agent spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitudes

• The SKOV and SKOV TR cells were

  2025-02-18

  

  The SKOV3 and SKOV3TR Ki16198 were exposed to stepwise increased concentration of paclitaxel with or without a different concentration of autophagy inhibitor (3-MA or HCQ) to further evaluate whether suppression of autophagy affected the growth and drug sensitivity of ovarian cancer cells in vitro.

• br Exocytosis of GLUT by autophagy br Conclusion br

  2025-02-18

  

  Exocytosis of GLUT4 by autophagy Conclusion Conflict of interest Ethics statement Antigen processing and presentation Adaptive immune response has to be instructed to identify and eliminate specific pathogens or foreign entities defined by their antigenic determinants. Processed antig

• Polyphenols like flavonoids have the potential to penetrate

  2025-02-18

  

  Polyphenols like flavonoids have the potential to penetrate into lipid bilayers which is vital for enabling protection against oxidation. Rosmarinic High-sensitivity cell counting kit is a natural polyphenol antioxidant isolated from Sphaeranthus amaranthoides. Polyphenols can inhibit the propagatio

• Here we investigate the ATM to ATR

  2025-02-18

  

  Here, we investigate the ATM to ATR switch in normal human fibroblasts (82-6 cells) after irradiation with γ-rays, or high LET 56Fe and 28Si and moderate LET 16O particles. Our data provide important evidence of LET dependence on the transition of ATM to ATR as well as end resection at the sites of

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